http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8301449-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-753 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 |
| filingDate | 1982-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a079d6172a1fb1d237e73b48c4d11e63 |
| publicationDate | 1983-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-8301449-A1 |
| titleOfInvention | Method for the preparation of intermediary compounds of carbacyclin |
| abstract | Process for the preparation of bicyclic ketones containing protected hydroxy groups of general formula I $ (8,) $ in which, R1 represents the residue -CH2OR2 where R2 represents benzyl, dimethyl-tert.-butylsilyl, diphenyl-tert.-butylsilyl, dimethylphenylsilyl , tribenzylsilyl or tetrahydropyranyl, $ (4,) $ where R2 has the same definition as above, R4 is hydrogen or methyl and R5 a saturated or unsaturated, straight or branched alkyl residue, substituted or not by atoms fluorine, chlorine, radicals 1,2-methylene, 1,1-trimethylene, or methoxy or represents a CH2-X-aryl residue, in which X is a CH2 residue or oxygen and aryl, a phenyl or heterocyclic residue may be substituted by methyl, methoxy, fluorine, chlorine, bromine or a trifluromethyl residue, or $ (4,) $ with R2, R4, R5 as defined above, and R3 has the meaning given for R2 and is the same or different from R2 or forms with R2 the group $ (4,) $ in which R6 and R7, identical or different, represent hydrogen, alkyl, cycloalkyl. It is characterized in that a ketonic acid containing protected hydroxy groups of formula II $ (6,) $ is reacted with a triphenyl- (phenyliminovinylidene) -phosphorane and then with alcohols. The carbacyclines thus obtained as intermediate products represent starting compounds for the preparation of prostacyclin, with pharmaceutical activity. |
| priorityDate | 1981-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.