abstract |
HuIFN-alpha proteins which, under SDS PAGE conditions, suitable for separation, exhibit narrow bands of stained proteins at 16600, 16980, 17380, 17580, 18410, 18840, 19050, 19500, 20420, 20890, 21380, 21880, and 22910 "Daltons", each of the proteins having antiviral interferon activity in various interferon test systems as illustrated in FIG. 2. Rabbit antibodies raised against each of the twelve individual species from 16980 Daltons up to 22910 Daltons react against all these species. Interferon proteins are produced by subjecting a solution containing Le-form human interferon proteins to antibody affinity chromatography. |