| abstract |
Pyridine derivatives represented by the following general formula: (FORMULA) or R1, R2, R3 and R4, which may be identical or different, each represent a hydrogen atom or a lower alkyl group, or R1 and R2, or R3 and R4, serve to form together a hetero ring in combination with the adjacent nitrogen atom, A1 and A2, which can be identical or different, each represent an alkylene group or an alkylene group substituted by hydroxy, Y1 and Y2, which may be the same or different, each represents an oxygen or sulfur atom, and Z represents (FORMULA) or the pharmaceutically acceptable acid addition salts thereof. These compounds exhibit pharmacological effects such as acceleration of phagocytosis of leukocytes, acceleration of phagocytosis of macrophages, acceleration of production of spleen cells forming rosettes, and reduction of adjuvant arthritis, which makes them useful as drugs. |