http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8200644-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d743b59ae50ca79489082cb43339341 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-62 |
| filingDate | 1981-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a84862e80fb845b3b182c3e067f84ac |
| publicationDate | 1982-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-8200644-A1 |
| titleOfInvention | 5,6-o-isoalkylidene ascorbic acid derivatives |
| abstract | New condensation products between enediol cetolactones such as 5,6-0-isopropylidene ascorbic acid and 2-chloroethyl isocyanates showing potent anti-tumor activity probably without the release of alkylating agents in vivo . Although the structures of the products cannot be easily clarified, it appears that their activity is superior to that of BCNU (bis (2-chloroethyl) -N-nitrosourea) and parallel to that of nitrosourea NeCCNU (1- ( 4-trans-methylcyclohexyle) -3- (2-chlorotethyle) -3-nitrosouree), which is toxic and very effective. The preferred compounds are condensation products according to the formula (FORMULA) where R2 and R3 represent a lower alkyl group containing from 1 to 3 carbon atoms or H and hal-CH2-CH2-N = C = O (B) or hal represents I, Br or Cl. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0148094-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0148094-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4780549-A |
| priorityDate | 1980-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.