| abstract |
Novel thiazolidine and pyrrolidine derivatives represented by the general formula: (FORMULA) (wherein Q1 and Q2 each represent a methylene group or a sulfur atom, Z represents an alkylene group containing 1 to 3 carbon atoms, R1 represents a hydrogen atom, an alkyl group, an aromatic group or a heterocyclic group, R2 represents a hydrogen atom, an alkyl group, an acyl group, an aromatic group, a heterocyclic group or a substituted mercapto group, R3 represents a hydrogen atom or an alkyl group, R4 represents a hydrogen atom, an alkyl group an aromatic group, or R3 and R4 are taken together to form a pyrrolidine ring or a thiazolidine ring, and R5 represents a hydroxy group or an amino group, with the respective groups being optionally substituted by an alkyl group or an aromatic group). These compounds are prepared by condensing a sulfur-containing acylthiazolidinecarboxylic acid or sulfur-containing acylpyrrolidinecarboxylic acid with an amino acid. They are useful as antihypertensive agents. |