| abstract |
Easily split enzyme substrates for the quantification of proteases having the general formula R1 - p-Glu -A1 - A2 - NH - R2, wherein R1 = H or a protective group, preferably t-butyl-oxycarbonyl, benzyloxycarbonyl; A1 = Gly, Ala, Val, Leu, Ile, Ser, Thr, Pro, Pip, Phe or Tyr; A2 = Arg or Lys; R2 = an aromatic, possibly substituted, hydrocarbon group, wherein -NH-R2 is a physico-chemically determinably group, preferably a chromogenic or fluorogenic group which is split by a present enzyme and then forms a cleavage product of the formula H2N - R2 the amount of which can be quantified. Process for the production of said substrates. Method in the laboratory diagnostics of proteases using said substrates. |