abstract |
A universal CAR-T cell targeting HER2 and a preparation method therefor, the universal CAR-T cell comprising a chimeric antigen receptor, the chimeric antigen receptor comprising a targeting moiety, the targeting moiety comprising HCDR3, and the HCDR3 comprising an amino acid sequence as shown in SEQ ID NO:8. In addition to recognizing tumor antigens, the described universal CAR-T cell can also reduce immune rejection caused by allogeneic CAR-T therapy, prolong cell survival time, and improve anti-tumor effects. |