| abstract |
The present invention relates to a putty-type bone filler with a demineralised bone matrix (DBM) encapsulation in a polymer mixture. The formulation comprises a mixture of polymethyl methacrylate (PMMA), which is chemically activated by including methyl methacrylate (MMA) monomer, an allogeneic, freeze-dried and demineralised bone matrix (DBM), and a stable and biocompatible hydrogel made up of polyvinyl alcohol prepared in a water and ethanol (50/50) mixture. The bone filler has a low setting time, which allows it to be applied in situ. |