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filingDate 2022-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2022268884-A1
titleOfInvention Method and system to quantify and predict changes in lung function
abstract The present invention relates to a system and method to diagnose and predict an exacerbation for an individual, using electronically monitored expiratory lung function data and electronically monitored timing of inhalation of a bronchodilator. The method comprises the steps of computing a reference value or resting state value of at least one parameter indicating expiratory lung function of an individual, determining responsiveness of the individual to a bronchodilator using a non-linear time- series regression model, and estimation of amplitude and phase of the diurnal variation of the parameter for the individual using a regression analysis model. The reference value, responsiveness to bronchodilator, and the phase and amplitude of diurnal variation, are used to diagnose and predict occurrences of exacerbations for the individual.
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