http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022263559-A1

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-34
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-34
filingDate 2022-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_150ce335450f875ce6fec6a762660bf0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4832678577588328ef92152b8f8b961a
publicationDate 2022-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2022263559-A1
titleOfInvention Production of cross-reactive material 197 fusion proteins
abstract This invention relates to methods of producing a CRM197 fusion protein comprising expressing a nucleic acid encoding the CRM197 fusion protein in a prokaryotic cell, wherein the CRM197 fusion protein comprises a CRM197 polypeptide and a tag that comprises the amino acid sequence WSHPQFEK or a variant thereof. This allows CRM197 to be produced as a fusion protein in soluble form in prokaryotic host cell systems. Methods of production, CRM197 fusion proteins, encoding nucleic acids and vectors and host cells comprising the nucleic acids and vectors are provided.
priorityDate 2021-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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