http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022257106-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4aea8e41bfccb18ba400d9d44f65aa06 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate | 2021-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8aef34abfcff410d3b3386060f82efd7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_510b5c186c6883e9bbb1c7b9aece64f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0ab358750cfe68e7717c0c02687fd30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4399e607f1c69a410e0a6f77af406360 |
| publicationDate | 2022-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022257106-A1 |
| titleOfInvention | Humanized anti-human gpvi monoclonal antibody fab fragment and application thereof |
| abstract | Disclosed in the present invention are a humanized anti-human GPVI monoclonal antibody Fab fragment and an application thereof. Complementarity-determining regions (CDRs) of heavy and light chains of a rat anti-human GPVI monoclonal antibody are first analyzed and predicted; amino acid sequences of heavy and light chain variable regions of the rat monoclonal antibody are used as templates; amino acid sequences of heavy and light chain variable regions of a corresponding high-homology human IgG antibody are obtained by screening from a human IgG antibody database; a heavy chain Fd fragment and light chain of a humanized anti-human GPVI monoclonal antibody Fab are constructed by means of CDR grafting. Nucleotide sequences encoding the heavy chain Fd fragment and light chain of the humanized anti-human GPVI monoclonal antibody Fab can be expressed recombinantly; secreted and expressed antibody Fab can specifically bind to a non-reducing human GPVI protein, inhibit binding of human GPVI to human collagen, and can be used for clinical treatment of platelet GPVI-related diseases. |
| priorityDate | 2021-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 150.