| abstract |
The present disclosure provides reconstituted epitopes derived from viruses of the Flaviviridae family, as well as various polypeptides comprising the reconstituted epitopes disclosed herein. Specifically, the E protein of viruses of the Flaviviridae, and any domains thereof, particularly, the Dill domain, that comprise the reconstituted epitope of the present disclosure. The invention further provides vaccines, and compositions comprising the reconstituted epitopes, as well as therapeutic and prophylactic methods thereof. |