http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022254182-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2c666474ffc0184da7e8aafe5f0b324d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4716 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 |
| filingDate | 2022-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e84ec89cdc13de873114dbb2959d5140 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfa3da6ab4292933847eabb18937ea34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e49eba15637da025369d784ed4e2f4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_648308c97360d877e898fb92417e4433 |
| publicationDate | 2022-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022254182-A1 |
| titleOfInvention | Screening for the effects of complement protein changes |
| abstract | Aspects of the present invention relate to the detection of binding events associated with a protein complex comprised of a protease deficient Complement Factor I (Fl) protein. Certain embodiments of the present invention provide for a protein complex comprising a Complement Factor I, C3b and further comprising at least one other protein from Complement Factor H (FH), Factor-H-like protein 1 (FHL-1), soluble membrane cofactor protein (sMCP), and soluble complement receptor 1 (sCR1 ), wherein the Complement Factor I comprises at least one mutation that causes inactivation of Complement Factor I protease activity. Further embodiments of the present invention provide for a protein complex comprising a Complement Factor I, C4b and further comprising at least one other protein from soluble complement receptor 1 (sCR1 ), soluble membrane cofactor protein (sMCP) and C4b binding protein (C4bp), wherein the Complement Factor I comprises at least one mutation that causes inactivation of Complement Factor I protease activity. |
| priorityDate | 2021-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.