| abstract |
Provided are an acid salt of a crystalline CSF-1R inhibitor, and a preparation method therefor and the use thereof, wherein the CSF-1R inhibitor is the compound 3,3-dimethyl-N-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)-2-oxopyrrolidine-1-carboxamide having the structure of formula (I). The crystalline acid salt compound can greatly improve the physicochemical properties such as solubility, hygroscopicity and chemical stability of the compound of formula (I) in a free state, and meet the requirements for industrial production and clinical drug preparation development. The crystalline acid salt compound can be widely used in the preparation of a drug for treating cancers, tumors, autoimmune diseases, metabolic diseases or metastatic diseases. |