| abstract |
An anti-SARS-CoV-2 drug and an application thereof. The drug comprises 9-methoxycanthin-6-one and/or a derivative thereof, and the derivative comprises canthin-6-one, 9-methoxycanthin-6-one N-oxide, 5-hydroxymethyl-9-methoxycanthin-6-one or 1-hydroxy-9-methoxycanthin-6-one. The 9-methoxycanthin-6-one and/or a derivative thereof may be used as an anti-SARS-CoV-2 drug, and may be combined with the Spike protein of SARS-CoV-2 and/or ACE2 of human cells, so that the Spike protein of SARS-CoV-2 is prevented from combining with ACE2 of human cells, and SARS-CoV-2 is prevented from entering cells, thereby treating SARS-CoV-2. |