| abstract |
Provided herein are compositions and methods for treating autoimmune, alloimmune, inflammatory, and mitochondrial conditions. Specifically, the disclosure provides a method of treating an alloimmune, autoimmune, inflammatory, or mitochondrial condition in a subject, the method comprising: administering a calcineurin inhibitor and a cytochrome p450 inhibitor, wherein calcineurin inhibitor comprising cyclosporine, tacrolimus, pimecrolimus, or analogs or derivatives thereof. Further disclosed are cytochrome p450 inhibitors that can be used for the method. |