| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b3a01ce5933845ca7a9f422e511293e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0789 |
| filingDate |
2021-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f98399b673df1055d83987281791653
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caee25b93bc5b2f16472065fad02afff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cffbd1e4beeb0a4d3ce3ae64f37b6d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6fe59d4a77b4f5e77e92ba931b4b931
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e9a843c0ebaf9f2ed54611c017b66b3 |
| publicationDate |
2022-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2022241617-A1 |
| titleOfInvention |
Plasmid, stem cell and application |
| abstract |
Provided are a TALEN/TALENickase-mediated non-viral gene targeting plasmid and an iPSCs stem cell having an N-terminal for fusion of an isoleucine zipper and integrated with a TRAIL expression box and an application of the stem cell. The sequence of the plasmid is shown as SEQ ID NO:1, and the plasmid is combined with a gene editing tool TALEN to achieve site-specific integration of a therapeutic gene TRAIL. TRAIL-iMSCs sustainably express TRAIL, and have the effect of inducing apoptosis on multiple types of tumor cells. |
| priorityDate |
2021-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |