| abstract |
The invention relates to compositions and binding agents specifically binding the Spike protein of Corona viruses via at least two different binding sites and potently neutralizing coronaviruses, in particular sarbecoviruses, such as SARS-CoV-1 and SARS-CoV-2. The compositions or agents specifically bind to epitopes of the Receptor binding domain (RBD) of the Spike protein characterized in that both epitopes are conserved over multiple clades of the sarbecoviruses, providing broadly neutralizing pan-specific antibody-based compositions thereby reducing viral escape. Application and uses of these agents and compositions are further part of this invention. |