abstract |
A method of estimating insulin on board (IOB) for a given glucose sensitive insulin (GSI) in a subject is provided. The method comprises the steps (i) for the given GSI, providing at least one rate constant (r c ) as function of glucose concentration (r c (G)), (ii) providing for a period of time a continuous blood glucose log G(t) from the subject, (iii) providing for the period of time 5 an insulin dose log I(t) from the subject, (iv) based on rc(G) and G(t), calculating for each rc a rate constant as function of time (r c (t)), and (v) based on the at least one r c (t) and I(t) and using an estimating algorithm, calculating an estimated IOB for the subject. |