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filingDate 2022-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2022234030-A1
titleOfInvention Insulin on board for glucose sensitive insulin
abstract A method of estimating insulin on board (IOB) for a given glucose sensitive insulin (GSI) in a subject is provided. The method comprises the steps (i) for the given GSI, providing at least one rate constant (r c ) as function of glucose concentration (r c (G)), (ii) providing for a period of time a continuous blood glucose log G(t) from the subject, (iii) providing for the period of time 5 an insulin dose log I(t) from the subject, (iv) based on rc(G) and G(t), calculating for each rc a rate constant as function of time (r c (t)), and (v) based on the at least one r c (t) and I(t) and using an estimating algorithm, calculating an estimated IOB for the subject.
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