abstract |
The present application provides a liposomal composition that multivalently displays a specific glycan ligand, or combination of specific glycan ligands, to specifically target CD33 on microglial cells. Multivalent engagement of CD33 with glycan ligands in the liposomal composition are useful in modulating microglial cell function, particularly as a therapeutic for the preventing, treating or delaying progression of Alzheimer's disease. |