| abstract |
Provided are a nasal drop preparation containing genetically engineered stem cell-derived vesicles and a use thereof in treatment of cerebral neurovascular diseases. Specifically, provided are a nasal drop preparation which takes an active substance in stem cell-derived vesicle contents having nerve cell targeting capabilities as a main active ingredient and a preparation method therefor, and a use of the preparation in treatment of Alzheimer's disease. After the preparation is administered by dropping the nasal cavity, the main ingredient of the preparation can effectively penetrate the blood brain barrier and is taken up by microglia and nerve cells, so that the main active ingredient in the stem cell-derived vesicles is released, and a significant inflammation inhibition effect is generated; moreover, the expression level of amyloid precursor protein hydrolase BACE1 is reduced, the expression level of ADAM10 is maintained, and generation of amyloid Aβ is inhibited, thereby effectively preventing or treating neurodegenerative diseases such as the Alzheimer's disease. |