http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022227927-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G75-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G75-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G75-00 |
| filingDate | 2022-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_646a7d112710ff3e5a3b901e54f471f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8132882cfc64c9a18ba37d6fec631cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac08c66bfea37931cadabaf38bf4fbc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9d9b02f073010be052883d3ff7983e3 |
| publicationDate | 2022-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022227927-A1 |
| titleOfInvention | Degradable polymer material, and self-assembled nano-composite and application thereof |
| abstract | The present invention provides a degradable polymer material, and a self-assembled nano-composite and an application thereof. The polymer material is a polydisulfide cation material, and a polymer composite with guanidine group-containing disulfide as the main chain is formed by self-assembly of the polydisulfide cation material and biological macromolecules of nucleotides and proteins. After the polymer composite of the present invention enters cells, under the action of GSH in the cytoplasm, the main chain of a carrier can be rapidly degraded to release encapsulated biological macromolecules into the cytoplasm. Therefore, the material of the present invention is less toxic to cells and has good cytocompatibility. The polymer composite of the invention has high efficiency in an intracellular delivery process, low production cost, and low toxicity, can effectively deliver a variety of biological macromolecules into cells without chemical modification and without affecting its biological activity, and can be applied as carriers in intracellular delivery of plasmids, mRNAs, and proteins. The structure of the polydisulfide cation material is shown in formula (1). |
| priorityDate | 2021-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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