http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022226425-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29c9b2802456a92159cc3004008de325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0a58ae70fb1ee6be0b00f90f259ce90 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-00 |
| filingDate | 2022-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ca241ab35818b6074a0fff34aa10f90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ea0e35e4c10ca996a96229b89b68a4b |
| publicationDate | 2022-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022226425-A1 |
| titleOfInvention | Site-specific glycan remodeling of lysosomal enzymes and applications thereof |
| abstract | The present disclosure provides compounds useful for enzymatic glycan remodeling of a glycoprotein. Also provided is a method for remodeling a glycoprotein using M6P-glycan oxazolines in a one-pot deglycosylation/transglycosylation process, which may enable siteselective M6P-glycan remodeling of glycoproteins to obtain homogeneous products. The remodeled glycoprotein (such as a recombinant human acid α-glucosidase) may have enhanced affinity for the CI-MPR, increased uptake by a cell, and improved therapeutic efficacy compared to the original glycoprotein. A method of treating Pompe disease using a glycanremodeled lysosomal enzyme is also provided. |
| priorityDate | 2021-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 812.