| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96eddd31165955882708d73c89118259 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y503-02002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-90 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-52 |
| filingDate |
2022-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aea28dca64ab7351e9be47180da0d629
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50524792ccc2f28b70066e9207a8ac50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f90e25c93a3fa765fc1066836d251d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c08489fee402a9f67845d3318f927b9 |
| publicationDate |
2022-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2022226190-A1 |
| titleOfInvention |
Synthesis of 3-hydroxypropionic acid via hydration of acetylenecarboxylic acid |
| abstract |
An in vitro and/or in vivo method of producing malonic semialdehyde (MSA) or an anion or salt thereof and/or 3-hydroxypropionic acid (3-HP) or an anion or salt thereof is provided herein. The method may comprise two steps: (1) hydrating acetylenecarboxylic acid (ACA) or an anion or salt thereof by reacting the ACA or an anion or salt thereof with an ACA-hydrating enzyme to form a reaction product comprising malonic semialdehyde (MSA) or an anion or salt thereof; and (2) reacting the reaction product comprising MSA or an anion or salt thereof with one or more oxidoreductases in an oxidation-reduction (redox) reaction to produce 3-HP or an anion or salt thereof. A pair of oxidoreductases may additionally recycle a cofactor, such as NADPH or NADH. Recombinant microbes and compositions are also provided herein which may include ACA-hydrating enzymes or variants thereof, and/or one or more oxidoreductase enzymes. |
| priorityDate |
2021-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |