abstract |
The present invention relates to a recombinant adeno-associated virus (AAV) and an application thereof. The present invention further relates to an AAV purification method and a purified AAV obtained thereby. The AAV in the present invention has organ or tissue targeting performance and/or high solid heart rate and/or can avoid neutralizing an antibody to a certain extent, such that the AAV can be used as a delivery vector of a therapeutic gene for the treatment of a related disease. The purification method in the present invention can change the target organ delivery capability of the AAV, and improve the liver transduction specificity of the AAV. |