http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022222203-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6d5f25e113f0abe6abf99f5fe774fec |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-40 |
| filingDate | 2021-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be8201bbc42b63b9c9e85d5c32c9f15c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_598eaf8cc8b13f3dc24a167f4a1944a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e763c75fcc9b8a9e1cde224568a6854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ffce65fcc5e7661ee50a1696c177f0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee9eb3ff97492424744f20697d770f5e |
| publicationDate | 2022-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022222203-A1 |
| titleOfInvention | Method for preparing trisubstituted indole compound by using one-step method |
| abstract | Disclosed is a method for preparing a trisubstituted indole compound by using a one-step method. The present invention belongs to the technical field of pharmaceutical intermediate synthesis. In the present invention, the trisubstituted indole compound has a structure as represented by formula I, wherein R1 is alkyl, phenyl, benzyl, 2-isopropylphenyl or naphthyl; R2 is alkyl; R3 is alkyl, phenyl or a derivative thereof, and R4 is hydrogen, 4-methyl or 7-methyl/Cl/Br. The preparation method comprises the following steps: sequentially adding acetonitrile, 1-substituted indole and brominated sulfoxide imine; stirring and mixing to react thoroughly, and then stirring same at room temperature to react thoroughly; and performing column purification to finally obtain the indole trisubstituted compound. In the preparation method of the present invention, a highly-active trisubstituted indole is prepared by using a two-component reaction without additives and catalysts. The operation is simple, the reaction yield is high, and the product is easy to purify. The raw materials which are used are inexpensive and readily available. The reaction conditions are simple, mild and environmentally-friendly, have excellent substrate suitability, and obtain very high yields for most compounds. |
| priorityDate | 2021-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.