http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022221591-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8adaddc602ad7cb7f9e2d550681bb36d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f0d61d62d86c276f17f51948cdebc45 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06N3-084 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06N3-044 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06N3-045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B40-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B20-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-00 |
| filingDate | 2022-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47a066600f06f48c4b8dd3ecbbf1925a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_243366651ed0c837cc3b5946cb506a85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed87ed311980426faa88aa326f27ccd6 |
| publicationDate | 2022-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022221591-A1 |
| titleOfInvention | Multi-channel protein voxelization to predict variant pathogenicity using deep convolutional neural networks |
| abstract | A system includes at least a voxelizer, an alternative allele encoder, an evolutionary conservation encoder, and a convolutional neural network. The voxelizer accesses a three-dimensional structure of a reference amino acid sequence of a protein and fits a three-dimensional grid of voxels on atoms in the three-dimensional structure on an amino acid-basis to generate amino acid-wise distance channels. The alternative allele encoder encodes an alternative allele sequence to each voxel in the three-dimensional grid of voxels. The evolutionary conservation encoder encodes an evolutionary conservation sequence to each voxel in the three-dimensional grid of voxels. The convolutional neural network applies three-dimensional convolutions to a tensor that includes the amino acid-wise distance channels encoded with the alternative allele sequence and respective evolutionary conservation sequences and determines a pathogenicity of a variant nucleotide based at least in part on the tensor. |
| priorityDate | 2021-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.