| abstract |
The present invention relates to compounds represented by Formulae (I) to (V), or a racemate, enantiomer, diastereomer, pharmaceutically acceptable salt, solvate, hydrate, or derivative thereof, and compositions thereof. In various aspects, the present invention also relates to methods of reducing or inhibiting ribonucleotide reductase (RNR), poly ADP-ribose polymerase (PARP), and/or homologous recombination (HR) repair using said compounds. In some aspects, the present invention relates to methods of inducing at least one double strand break (DSB) using said compounds. In another aspect, the present invention relates to methods of trea ting or preventing cancer (e.g., ovarian cancer, BRCA-wild type cancer, etc.) using said compounds. |