abstract |
The present invention relates to an improved method of reprogramming human adult cells into hiPSCs, the method comprising supplementing the reprogramming medium or the reprogramming medium and the expansion medium with one or more biological molecules selected from Hepatocyte Growth Factor (HGF), Interleukin 6 (IL6) together with soluble Interleukin 6 Receptor (slL6R), and Neuregulin 1 (NRG1). The method of the invention dramatically increases the reprogramming efficiency. |