| abstract |
A small-molecule compound having a substituted phenyl spiro[indoline-3,3'-pyrrolidine] structure. The structure is represented by general formula I, and the definition of each substituent is as described in the description and the claims. The compound of the present invention can inhibit MDM2-p53 and MDMX-p53 protein-protein interactions, serves as a small-molecule inhibitor for MDM2-p53 and MDMX-p53 protein-protein interactions, and is used for preparation of a medicament for preventing and/or treating MDM2 and MDMX-related diseases, in particular tumors. |