| abstract |
Provided are a dihydropyrimidoisoquinolinone derivative represented by formula I, and a tautomer, stereoisomer, hydrate, solvate, pharmaceutically acceptable salt or prodrug thereof. The present invention has an obvious GPR84 antagonistic effect, good druggability and is safe; L1 is -NH-, -N(C1-C5alkyl)- or -S-; V is absent or is -O-; L2 is absent or L2 is a C1-C5 alkylene, a C 2-C4 alkenylene having a double bond, or a C2-C4 alkynylene having a triple bond; and the definitions of R2, R3, R4, R5, R6, R7, and R8 are as described in the description. |