Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f47c750954e13a1ed0be96c1bf1c51c7 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
filingDate |
2022-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac2bdb222d8c8bc2c022722cebaa3fff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a42d4a79e640097ec879dd5d287be09 |
publicationDate |
2022-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-2022216876-A1 |
titleOfInvention |
Cancer treatment by targeting proteins or interactions of ephrinb-rgs3-kif20a-sept7 axis |
abstract |
A method of treating cancer in a subject by targeting at least one of KIF20A, SEPT7, RGS3 and EphrinB or disrupting protein-protein interaction in the EPHRINB-RGS3-KIF20A-SEPT7 axis. The method entails administering to the subject an RNA-based inhibitor such as an siRNA, shRNA, or miRNA or a peptide inhibitor which targets at least one of KIF20A, SEPT7, RGS3 and EphrinB or blocks the binding of KID20A to RGS3 and/or SEPT7 or the binding of EphrinB and RGS3. |
priorityDate |
2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |