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filingDate 2022-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f6d92c8d5fd8d1856534ce6840c2277
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publicationDate 2022-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2022214496-A1
titleOfInvention Device for fabricating a perfusable three-dimensional tissue construct
abstract The invention relates to a device for fabricating a perfusable three-dimensional tissue construct as well as to its manufacture and use. The device comprises a chamber in which the tissue construct may be cultivated, the chamber comprising an inlet and an outlet for perfusing the tissue construct, and a sacrificial scaffold fixed in the chamber. The sacrificial scaffold comprises a thermo-responsive polymer, the thermo-responsive polymer being not dissolvable in water at human body temperature and becoming dissolvable in water at a temperature below 30°C, preferably below 25°C. The sacrificial scaffold comprises at least one filament extending from the inlet to the outlet such that dissolution of the sacrificial scaffold provides for a liquid channel from the inlet to the outlet. The sacrificial scaffold seals the inlet and/or the outlet such that dissolution of the sacrificial scaffold after receiving a cultivation matrix in the chamber provides for a liquid channel from the inlet to the outlet through the cultivation matrix.
priorityDate 2021-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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