| abstract |
The present invention relates to the provision of a pharmaceutical composition that contains a compound represented by general formula (I), said compound being effective for the treatment, amelioration or prevention of κ-opioid receptor-related diseases and symptoms of various types (for example, pain, pruritus or substance addiction) with reduced or no sedation or drug aversion, a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof or a solvate thereof. Examples of the treatment, amelioration or prevention of the κ-opioid receptor-related diseases and symptoms of various types include the treatment, amelioration or prevention of pain, pruritus or substance addiction, in particular, the treatment, amelioration or prevention of drug addiction. |