| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7d5e76c8010e2279cb7988aa35d0216b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b2ba2973e1622fea141b69f5f684549
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71b944100daf03103e6704d7474fd127 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-02 |
| filingDate |
2022-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7c5e24221977f8134737e3bf3dc39f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d76f1a81caae6ddb8219c36b4437ecc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8de3de0f4d6cae8f3e6283209aa9b12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7946753709b4825ab8c824a071fabf38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5bf2fa2899e818d5660d2303412b6b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1c39e5a84955dda19179f444b209d40 |
| publicationDate |
2022-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2022207425-A1 |
| titleOfInvention |
Process for the preparation of cyclen |
| abstract |
The present invention relates to a process for the preparation of Cyclen, in its turn widely employed in the manufacturing of a variety of macrocyclic gadolinium complexes for use as MRI contrast agents. The said process comprises an efficient coupling of glyoxal with triethylene tetramine and the subsequent reduction of the obtained intermediate derivative with an aluminium based reducing agent. The process is particularly advantageous for the industrial scale as it avoids the use and/or formation of hazardous compounds and further provides for Cyclen manufacturing in high yields and purity. |
| priorityDate |
2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |