| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ae0f07170be484b5f269bee22bbeb13 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02 |
| filingDate |
2022-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_694047b150fb84f7aaf703ca7f5d2bd8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee2641bed2865660bcf893fa48ae06f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1860fe4219d264283949223ec3bf738
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da1e8c5d6b0b962d87c045776dc43f69
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f564543bb20b4a980fb001daa63bacb3 |
| publicationDate |
2022-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2022206870-A1 |
| titleOfInvention |
Preparation and purification process of monomethyl auristain e compound |
| abstract |
Provided is a preparation and purification process of MMAE. The process has mild synthesis and purification conditions, can effectively prevent the change of product chirality caused by excessively high temperature, greatly reduces generation of degradation impurities, and increases the purity and yield of the product. In addition, the preparation and purification process has good stability and is more suitable for scale-up production. The MMAE prepared has purity of higher than 99%, and can perfectly meet clinical drug requirements. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116239513-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116239513-A |
| priorityDate |
2021-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |