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filingDate 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f46ad511a258dbad8121bfb2b275cf2
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publicationDate 2022-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2022197988-A1
titleOfInvention Lipid-based nanoparticle delivery system for hydrophilic charged compound
abstract A lipid-based nanoparticle (LNP) with high DL ratio and normalized release. The LNP of the present invention comprises an outer lipid monolayer encapsulating a plurality of lipid-active pharmaceutical ingredient (API) complexes, wherein each lipid- API complex comprises a complex of anionic lipid and API wherein the API comprises a positively charged form of an API and wherein the outer lipid monolayer of the LNP comprises neutral lipids. The present invention further comprises a method of preparation of the LNP of the present invention.
priorityDate 2021-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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