http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022192503-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c0ae312be843476e245cdbe94c3eb44d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0032 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0446 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-0066 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B23-00 |
| filingDate | 2022-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_919abb184ee1cb4346eb1b4f5207c33c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02bd06617924e24c9ffed40022a90a28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5adc33624c52a9a1c807fd2f42e7f818 |
| publicationDate | 2022-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022192503-A1 |
| titleOfInvention | Heptamethine carbocyanine dye-cross-bridged tetraamine cyclam (ctc) chelator conjugates, their stable complexes with copper-64, and uses thereof |
| abstract | Embodiments of the present invention relate to conjugates of the near infrared (NIR) heptamethine carbocyanine dye (HMCD) with chelator-radiometal complexes, radiopharmaceutical formulations comprising such complexes and their use, e.g. in internal radiotherapy and/or imaging of cancer. Provided are DZ-1-cross-bridged tetraamine cyclam (CTC) conjugates with optional linker L (DZ-1-(L)-CTC), wherein the CTC chelator is complexed with copper-64 (64Cu). The CTC may be a chelator selected from the group comprising CB-TE2A, DiAmSar, derivatives or combinations thereof. Copper complexes comprising DZ-1-(L)-CTC may provide improved serum stability compared to previously known copper complexes while retaining tumor targeting and providing good imaging quality. The present invention also relates to methods of forming the complexes, pharmaceutical compositions comprising the complexes, methods of using the complexes or pharmaceutical compositions, methods of imaging and/or radiotherapy of cancer cells, tissues, soft and solid tumors, and/or their metastases, kits for imaging and/or radiotherapy, and the like. |
| priorityDate | 2021-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 203.