| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43fe117d5e377852bbddf9b05a6702ba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b2021cafa8df7b0dec20ae2c7682f639 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6891
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0495 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 |
| filingDate |
2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe90bb6c9ba25c4fa79c99ecf5ed8241
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c99b2bd72cc7175fd2376a51c267d6f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2b00fb0d23b4b053ac5a87bf2f518f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_480030ed90ca210a8bd6495ee7f70d82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a18509c61d00f4c2253eda5f5120466d |
| publicationDate |
2022-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2022189304-A3 |
| titleOfInvention |
Aliphatic 18f-radiolabeling of a tetrazine precursor |
| abstract |
Up ontil now, only low reactivity Tzs can be radiolabeled via direct aliphatic SN2. Unfortunately, these structures display too low reactivity for in vivo bioorthogonal chemistry approaches. Highly reactive structures such as mono-unsubstituted tetrazines (H-Tzs) have been reported to be highly sensitive to base. Extensive degradation is observed which prevents isolation of meaningful amounts for imaging studies. In the present invention there is provided a method providing the possibility to radiolabel base sensitive tetrazine structures with significantly improved RCYs. Even tetrazines that were previously not accessible by applying "standard" aliphatic 18F-labeling strategies can be radiolabeled. This places new classes of 18F-fluorinated compounds within reach for application in PET imaginge studies such as for diagnosis of cancers. |
| priorityDate |
2021-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |