| abstract |
Antigen targeting agents that target brachyury as restricted and presented by MHC proteins are provided. The antigen targeting agent can be a T-cell, CAR construct, antibody, bi-specific antibody, or the like. Methods of treating cancers involving expression or overexpression of brachyury and methods of screening for patients likely to benefit from such treatment are provided. A novel tumor-associated antigen comprising a brachyury peptide presented by HLA-C*04:01 is provided. |