http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022183370-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e74277852f1aae0a3ff13f59a65456d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-02 |
| filingDate | 2021-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e4a04f56a2184c358879141c96608ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72f5b4428beb2b280c3a57a557417cb5 |
| publicationDate | 2022-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022183370-A1 |
| titleOfInvention | Electric cell impedance sensing-based method for antitumor medicament screening |
| abstract | Provided is an electric cell impedance sensing-based method for antitumor medicament screening, comprising: S1, performing a surface treatment with respect to an electrically-conductive chip provided with a microelectrode array; S2, laying tumor cells on the surface of the electrically-conductive chip; S3, performing a starvation treatment and a dosing effect subsequent thereto with respect to the tumor cells; S4, forming a polymeric hydrogel on the tumor cell and adding a chemokine; and S5, performing electric cell impedance detection in real-time to acquire impedance information of the cells, and performing medicament screening on the basis of the impedance information. By applying paclitaxel at different concentration gradients to human breast cancer cells, a cell colony invasion in a collagen type I gel is induced, thus effectively implementing efficient and stable electric cell impedance sensing detection during a cell invasion process in a three-dimensional substrate, and achieving the technical effect of real-time, unmarked, continuous dynamic detection for antitumor medicament quantitative screening. |
| priorityDate | 2021-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.