http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022179263-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d84aa8c4818bda002eded1de6d318389 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-00 |
| filingDate | 2021-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_819760f7f8b4062687b704e58849b13d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8db46177a7f0380ef85b8f40033126bd |
| publicationDate | 2022-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022179263-A1 |
| titleOfInvention | Starvation intervention method and application based on macronutrient component change and mtor signaling inhibitor |
| abstract | A starvation intervention method and an application based on the macronutrient component change and an mTOR signaling inhibitor. The present invention particularly relates to a method for suppressing appetite, reducing starvation, reducing body weight or body fat, and improving glucose tolerance. The method comprises administering, to a subject, an effective amount of an mTOR signaling pathway inhibitor or administering, to a subject, a low-protein diet, the low-protein diet having a protein content of less than 5% of the total energy in a macronutrient component. The low-protein diet can reduce body weight and body fat and improve metabolism; the mouse subjected to low-protein food treatment lacks a phenotype of retaliatory excessive dieting after the normal diet is recovered even under the condition that a starvation pathway is activated, and this phenomenon is related to an mTOR signaling in the hypothalamus. By inhibiting the mTOR signaling in the hypothalamus of the mouse subjected to limited feeding treatment, the phenotype of lack of excessive feeding when 1% of low protein is recovered to the normal diet can be simulated. |
| priorityDate | 2021-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.