| abstract |
ADGRG1 activity was found to promote myelination by its activity in pre-myelinating oligodendrocytes. Interventions made at various points along the ADGRG1-mediated myelination process can promote myelination. ADGRG1 activators, RhoA activators, ROCK activators, and cofilin inhibitors promote myelination. These myelinating agents may be applied in methods of treating demyelinating conditions, such as multiple sclerosis. |