| abstract |
The use of a ginkgo leaf extract (GLE) in the preparation of a drug for targeting senescent cells, inhibiting tumors or prolonging lifetime. The ginkgo leaf extract, which targets a tumor microenvironment and eliminates senescent cells, can promote tumor suppression by means of eliminating senescent stromal cells after combination with a chemotherapy drug. For a senescence-associated secretory phenotype (SASP), the GLE can also eliminate senescent cells therein in a targeted manner, thereby inhibiting the SASP. The GLE can further significantly prolong the lifetime of an animal, significantly prolong the survival time of the elderly, and improve the survival quality of an animal. |