http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022159783-A1

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filingDate 2022-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2022-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2022159783-A1
titleOfInvention Apparatus and methods for selective capture of mycobacteria
abstract A device for selectively capturing mycobacteria comprises a substrate and a capture polymer layer of poly-diallyldimethyl ammonium chloride, wherein the capture polymer layer is covalently linked onto the substrate via a UV-initiated polymerization reaction of a solution comprising diallyldimethyl ammonium chloride and a photoinitiator in water purged of dissolved oxygen, and wherein the UV exposure time is 30 seconds to 4 minutes at a power density of about 20 to about 25 mW/cm2. A kit can comprise the device. A microfluidic chip comprises at least a portion of at least one channel sidewall coated with a capture polymer layer of poly-diallyldimethyl ammonium chloride. A method for manufacturing the device includes plasma treating a substrate, providing a solution comprising diallyldimethyl ammonium chloride and a photoinitiator in water purged of dissolved oxygen, and coating the plasma-treated substrate via a UV-initiated polymerization reaction.
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