| abstract |
The present invention provides a desired antibody or antibody composition by modifying a thiol group chemically introduced into an antibody. More specifically, the present invention provides an antibody composition, etc., having desired properties, the antibody composition comprising (A) an antibody intermediate having an optionally protected bioorthogonal functional group represented by formula (A) (in the formula, Ab is a prescribed antibody, S is a sulfur atom, L is a divalent group, R is an optionally protected bioorthogonal functional group, and n is an integer of 1-8) or a salt thereof, and (B) a thiol-group-introduced antibody represented by formula (B) (in the formula, Ab and n are the same as in formula (A), and SH is a thiol group) or a salt thereof. |