| abstract |
The present disclosure relates generally to antigen-binding polypeptides, e.g. , antibodies, and antigen-binding fragments thereof, that specifically bind to the spike (S) protein of a coronavirus, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the disclosure are useful for inhibiting or neutralizing coronavirus activity, thus providing a means of treating or preventing coronavirus infection. Also provided are recombinant nucleic acids, recombinant cells, compositions and methods useful for identifying or producing such antibodies and antigen-binding fragments, as well as methods of using such antibodies and antigen-binding fragments for treating, preventing, or ameliorating health conditions associated with viral infections ( e.g. , coronavirus infections). |