| abstract |
The present invention provides compounds that have a serotonin 5-HT2A receptor antagonist and/or inverse agonist activity, and pharmaceutically acceptable salts thereof, and also provides a serotonin 5-HT2A receptor antagonist and/or inverse agonist composition that contains such a compound or salt. Provided are compounds represented by formula (I): (in the formula, R1 is a substituted or unsubstituted aromatic heterocyclic group, etc.; each R2 is independently a hydrogen atom, etc.; each R3 is independently a hydrogen atom, etc.; n is 1, etc.; the combination of (L1, L2) is (NH,N), etc.; R4 is a group represented by the formula (AAA): (in the formula, p and q are each independently 2, etc., Ra is substituted or unsubstituted alkyl, etc., each Xb is independently CRbRb', each Rb is independently a hydrogen atom, etc., each Rb' is independently a hydrogen atom, etc., each Xc is independently CRcRc', each Rc is independently a hydrogen atom, etc., each Rc' is independently a hydrogen atom, etc., Xd is CRd, etc., and Rd is a hydrogen atom, etc.); R5 and R6 are each independently a hydrogen atom, etc.; and R7 is a group represented by formula (BBB): (in the formula, A is CR11, etc., R9 is substituted or unsubstituted alkyloxy, etc., R10 is a hydrogen atom, etc., and each R11 is independently a hydrogen atom, etc.)), and pharmaceutically acceptable salts thereof. |