http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022136417-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12ebc103560b5cf6344bdb5298eeb7e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_372d65fb7991c41910726d38b09ac85b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d2e7fa9433e04fc27265b1d92b48e1d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1870024223df71c715c62d0edd723acb http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 |
| filingDate | 2021-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5831fa244caecb7d47cc30a3266a8eed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c61504d5584a505f6995019a85905f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78958c6ff712e62f60b7d61e1c899cc3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_532700b860df793e8c4f22ae459b2ab3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c8650cb75aa2c8a1d038145a5183dd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5abba2c53df9bf48bdbd9a29de2ca1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a724a597fd00138f99c351c1e886dcc3 |
| publicationDate | 2022-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2022136417-A1 |
| titleOfInvention | Pulsative gnrh administration for treating food intake related disorders |
| abstract | The present invention relates to the pulsatile administration of the gonadotropin- releasing hormone (GnRH) for the treatment of food intake related disorder related disorder such as obesity (overeating) and anorexia (undereating). The inventors demonstrated that a population of mutant mice expressing BoNT/B in GnRH neurons (Gnrh::cre;iBot overweight), in which the GnRH release is inhibited, did not only fail to reach puberty onset and showed hypogonadotropic hypogonadism, but also developed overweight and hyperleptinemia. Unexpectedly, they found that the increase in body weight in mutant mice persisted in adulthood despite a significant decrease in food intake. Using a mouse model of obesity inventors observed an altered pattern of pulsatile LH secretion and that the frequency of LH pulses is inversely correlated to body weight and adiposity demonstrating that the heavier the animals were getting the more the GnRH/LH pulsatile pattern was altered. The present inventors further demonstrated that pulsatile GnRH treatment can allow to restore a control/lean pattern of GnRH/LH release in obese mice, and that this pulsatile administration of a "lean pattern" of native GnRH peptide in obese mice normalized their cumulative food intake to levels comparable with lean mice. |
| priorityDate | 2020-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 218.