| abstract |
Genistein-loaded Phytosomes for treatment of Liver Cancer via Oral Administration The present invention provides phytosomes for improving solubility and bioavailability of Genistein extract, protecting it from metabolism by complexation with soy phosphatidylcholine (SPC), and using phospholipid in obtaining in-situ chylomicron. Different forms of Phospholipids were used in Genistein-loaded phytosomes preparation for treatment of liver cancer, includes: solid phospholipid (Lipiod® S100, Pure Soy phospholipid), liquid phospholipid with medium chain triglyceride oil (Phosal® 53 MCT), and liquid phospholipid with long chain triglyceride oil (Phosal® 75 SA). |